New Publication – Dorosh et al., 2014

Lyudmyla Dorosh, Nandahkishore Rajagopalan, Michele C. Loewen, Maria Stepanova (2014)  Molecular mechanisms in the selective basal activation of pyrabactin receptor 1: comparative analysis of mutants . Febs Open Bio 2014 DOI: 10.1016/j.fob.2014.05.001 .

This work represents a comparative computational analysis of the dynamics of the interactions between abscisic acid receptors and their downstream signalling target, Type2 protein phosphatases.  In particular the effect of sets of mutations on the basal or constitutive activity of the receptors is considered.