Olesya A. Kharenko; Devin Polichuk; Ken M. Nelson; Suzanne R. Abrams; Michele C. Loewen (2013) Identification and characterization of interactions between abscisic acid and human heat shock protein 70 family members J Biochem 154:383-391 [PDF]
This work represents a twist in our chemical proteomics strategy, having here applied it not to plant target tissues, but to human cell extracts. ABA is well known to have positive beneficial effects on human health, but the primary targets of ABA in mediating its effects remain enigmatic. Here we present evidence of an interaction between ABA and a heatshock protein, glucose responsive protein 78, involved in a variety of human conditions including diabetes and immunological responses and cancer.